Πλοήγηση ανά Θέμα "pharmacokinetic parameters"
Αποτελέσματα 1-4 από 4
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Advanced Non-linear Mathematical Model for the Prediction of the Activity of a Putative Anticancer Agent in Human-to-mouse Cancer Xenografts
(2020)Background/Aim: Mathematical models have long been considered as important tools in cancer biology and therapy. Herein, we present an advanced non-linear mathematical model that can predict accurately the effect of an ... -
In Mixed Lymphocyte Reaction, the Hypoxia-Inducible Factor Prolyl-Hydroxylase Inhibitor Roxadustat Suppresses Cellular and Humoral Alloimmunity
(2020)Hypoxia-inducible factor (HIF) prolyl-hydroxylase inhibitors are currently used for the treatment of renal anemia. Since HIF affects immune cells, we evaluated the effect of such a drug, the roxadustat, on adaptive immunity. ... -
Pharmacokinetic evaluation of linezolid administered intravenously in obese patients with pneumonia
(2019)Objectives: Altered linezolid pharmacokinetics (PK) in obese individuals has been hypothesized in previous studies. However, specific dosing recommendations for this population are still lacking. The main goal of this study ... -
A systems toxicology paracetamol overdose framework: accounting for high-risk individuals
(2019)The most commonly prescribed painkiller worldwide, paracetamol (acetaminophen, APAP) is also the predominant cause of acute liver failure (ALF), and therefore paracetamol-induced liver toxicity remains an important clinical ...